ChloroquineV1, Main, Exploration, bibRecord, 001C11

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Identifieur interne : 001C11 ( Main/Exploration ); précédent : 001C10; suivant : 001C12

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Auteurs : Christophe Biot [France] ; Wassim Daher [France] ; Natascha Chavain [France] ; Thierry Fandeur [France] ; Jamal Khalife [France] ; Daniel Dive [France] ; Erik De Clercq [Belgique]

Source :

Journal of Medicinal Chemistry [ 0022-2623 ] ; 2006.

RBID : Hal:hal-00099876

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

Url:

https://hal.archives-ouvertes.fr/hal-00099876

DOI: 10.1021/jm0601856

Affiliations:

Belgique, France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000064
to stream Hal, to step Curation: 000064
to stream Hal, to step Checkpoint: 000234
to stream Main, to step Merge: 001C21
to stream Main, to step Curation: 001C11

Le document en format XML

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<author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
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</author>
<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
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</author>
<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
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              <country key="FR"></country>
            </address>
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          </desc>
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          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>42 rue Paul Duez 59000 Lille</addrLine>
              <country key="FR"></country>
            </address>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-20675" status="INCOMING">          <orgName>Rega Institute for Medical Research</orgName>
          <desc>            <address>              <addrLine>K.U.Leuven, B-3000 Leuven</addrLine>
              <country key="BE"></country>
            </address>
          </desc>
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          </listRelation>
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          <desc>            <address>              <country key="FR"></country>
            </address>
          </desc>
        </org>
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</hal:affiliation>
<country>Belgique</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1021/jm0601856</idno>
<series><title level="j">Journal of Medicinal Chemistry</title>
<idno type="ISSN">0022-2623</idno>
<imprint><date type="datePub">2006</date>
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<front><div type="abstract" xml:lang="en">              <p>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
</noRegion>
<name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
<name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
</country>
<country name="Belgique"><noRegion><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities

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